Detalhe da pesquisa
1.
In situ identification of cellular drug targets in mammalian tissue.
Cell
; 185(10): 1793-1805.e17, 2022 05 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35483372
2.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Cell
; 182(4): 1009-1026.e29, 2020 08 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32730809
3.
Chemistry Takes Center Stage for Identifying Cancer Targetability.
Cell
; 173(4): 815-817, 2018 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29727668
4.
Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
Cell
; 168(3): 527-541.e29, 2017 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28111073
5.
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.
Cell
; 168(3): 517-526.e18, 2017 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28111075
6.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Cell
; 171(3): 696-709.e23, 2017 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-28965760
7.
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.
Cell
; 166(1): 126-39, 2016 Jun 30.
Artigo
Inglês
| MEDLINE | ID: mdl-27368101
8.
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Mol Cell
; 83(10): 1725-1742.e12, 2023 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37084731
9.
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
Nat Immunol
; 19(9): 942-953, 2018 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30111894
10.
A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells.
Cell
; 161(7): 1668-80, 2015 Jun 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26091042
11.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26046436
12.
Enzyme inhibitor discovery by activity-based protein profiling.
Annu Rev Biochem
; 83: 341-77, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24905785
13.
The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids.
EMBO J
; 43(4): 533-567, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38316990
14.
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution.
Annu Rev Pharmacol Toxicol
; 64: 507-526, 2024 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37722721
15.
Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome.
Cell
; 150(2): 426-40, 2012 Jul 20.
Artigo
Inglês
| MEDLINE | ID: mdl-22817901
16.
Global profiling of phosphorylation-dependent changes in cysteine reactivity.
Nat Methods
; 19(3): 341-352, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35228727
17.
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids.
Nat Chem Biol
; 19(3): 378-388, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36782012
18.
Remodeling oncogenic transcriptomes by small molecules targeting NONO.
Nat Chem Biol
; 19(7): 825-836, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36864190
19.
Assigning functionality to cysteines by base editing of cancer dependency genes.
Nat Chem Biol
; 19(11): 1320-1330, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-37783940
20.
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.
Nat Chem Biol
; 19(7): 815-824, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36823351